The Premier League side announced the appointment in a statement on Friday, confirming that the Argentine will take charge from 18 November.
“Mauricio Pochettino has agreed to become the Manchester United men’s head coach from 18 November.
“The club has reached an agreement with the US Soccer Federation for Mauricio and his staff to be released after the conclusion of their responsibilities with the US Men’s National Team,” the statement read.
Pochettino’s appointment follows the dismissal of Michael Carrick on Thursday after a disappointing start to the campaign.
The former Chelsea and Tottenham Hotspur manager is expected to take over a United side struggling in the Premier League, with the club sitting 18th in the table during the November international break.
The Red Devils have managed just one league victory so far this season, leaving the new manager with the task of turning around the club’s fortunes.
